Xenobiotics usually pass through a number of cells, such as the stratified epithelium of the skin, the thin cell layers of the lungs or G.I.T., the capillary endothelium, and the cells of target organ or tissue. The cell membrane (plasma membrane) surrounding all these cells are remarkably similar. It is approximately 100 A0 thick with […]
Mechanism of Xenobiotic Transfer | Toxicology
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Toxicity of Xenobiotic Chemicals: 4 Modifying Factors | Toxicology
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The following points highlight the four factors that modify the toxicity of xenobiotic chemicals. The factors are: 1. Factors Pertaining to Xenobiotic Chemicals 2. Factors Pertaining to Exposure 3. Factors Pertaining to Surrounding Medium 4. Factors Pertaining to Organisms. 1. Factors Pertaining to Xenobiotic Chemicals: (i) Physico-Chemical Properties: Actually the physico-chemical properties of a xenobiotic […]
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Mechanism of Selective Toxicity | Toxicology
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The selective toxicity of a chemical may be on account of any of the following mechanisms: 1. Due to Differences in Translocation Factors 2. Due to Differences in Biotransformation Reactions 3. Due to Presence or Absence of Receptors. 1. Selective Toxicity due to Differences in Translocation of Chemical: Actually gross morphological, anatomical and cytological differences […]