In this article we will discuss about:- 1. Definition of Selective Toxicity 2. Need of Selective Toxicity 3. Convincing Demonstration of Selective Toxicity in Man 4. Scientific Basis of Selective Toxicity 5. Advantages of Selective Toxicity. Definition of Selective Toxicity: Albert (1965) coined the term selective toxicity. Selective toxicity means that a chemical produces injury to […]
Selective Toxicity: Need and Advantages | Toxicology
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Biotransformation of Toxicants in Animals | Toxicology
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A xenobiotic (toxicant) may be absorbed into an animal via different routes. After absorption it is distributed to different parts of the body and, finally, is available for excretion. Many xenobiotics are known to undergo biotransformation while in the organs and tissues. Biotransformation is also termed metabolic transformation. Definition of Biotransformation: Biotransformation may be defined […]
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Phases of Biotransformation: 2 Phases | Toxicants | Toxicology
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The following points highlight the two main phases of biotransformation of toxicants. The phases are: 1. Phase I Reactions 2. Phase II Reactions. 1. Phase I Reactions: There are three types of Phase I reactions: i. Oxidation. ii. Reduction. iii. Hydrolysis. 1. Oxidation: The biotransformation of great variety of xenobiotic compounds involves oxidation process. The […]